联系方式
E-mail：zwang@cqu.edu.cn；QQ: 23140666; 实验室：理科楼LC721
研究方向
Ø 新型小分子荧光探针的设计、合成及应用：
1）生物体系内活性物种的检测和细胞成像；
2）等离子体活化水中ROS/RNS的特异性诊断；
Ø 功能分子导向的有机合成方法学研究；
Ø 药物导向的有机合成方法学；
代表性论文、专著和专利
[1] Chaofan Wang, Ling Fang*, Lingling Zhang, Ya Wang, Fang, Gao, Zhiyong Wang* Base-mediated unprecedented tandem cyclization reaction of nitrilimines and sulfur ylides: facile approaches to multifunctionalized pyrazolines. Org. Chem. Front. 2022, DOI：10.1039/D2QO00232A.
[2] Lijie Zhang, Ling Fang*, Hao Huang, Chaofan Wang, Fang Gao, Zhiyong Wang* Synthesis of Benzo[e][1,4]thiazepines by Base-Induced Formal [4+3] Annulation Reaction of Aza‑o‑quinone Methides and Pyridinium 1,4-Zwitterionic Thiolates J. Org. Chem. 2021, 86, 18156.
[3] Chaofan Wang, Ling Fang, Zhiyong Wang* Base-induced inverse-electron-demand aza-Diels-Alder reaction of azoalkenes and 1,3,5-triazinanes: Facile approaches to tetrahydro-1,2,4-triazines. Tetrahedron Lett. 2021, 79, 153303.
[4] Zhengqiang Wang, Xinchao Wang, Shengtao Zhang, Zhiyong Wang*, Fang Gao*, Hongru Li* Simple and prompt protonation of new dyes containing double conjugated imine bonds to strengthen the protection of copper in aggressive sulfuric acid solution, J. Mol. Liq. 2021, 341, 117402.
[5] Zhefeng Li*, Wending Hu, Zejun Li, Zhiyong Wang. Study on the Characteristics of Photovoltaic and Field Effect of Small Molecule Donors, IEEE Electr. Device L. 2020, 41, 1516-1519.
[6] Zejun Li, Wending Hu, Zhefeng Li*, Zhiyong Wang*. High performance n-type organic field-effect transistors based on halogenated derivatives of naphthalene tetracarboxylic diimides, Mat. Sci. Semicon. Proc. 2020, 120, 105273.
[7] Wei Luo, Wenpo Li,⁎ Jian Tan, Jie Liu,⁎ Bochuan Tan, Xiuli Zuo, Zhiyong Wang,⁎ Xin Zhang. A combined experimental and theoretical research of the inhibition property of 2-((6-chloropyridazin-3-yl)thio)-N,N-diethylacetamide as a novel and effective inhibitor for Cu in H2SO4 medium, J. Mol. Liq. 2020, 314, 113630.
[8] Haijun Huang;Yan Fu; Xiaojing Mu; Ziping Luo; Shengtao Zhang*; Zhiyong Wang*; Hongru Li*; Fang Gao*; Molecular self-assembly of novel amphiphilic topological hyperbranched polymers for super protection of copper in extremely aggressive acid solution, Appl. Surf. Sci. 2020, 529, 147076.
[9] Haijun Huang, Yan Fu, Fuhua Li, Zhenqiang Wang, Shengtao Zhang*, Xinchao Wang*, Zhiyong Wang*, Hongru Li*, Fang Gao* Orderly self-assembly of new ionic copolymers for efficiently protecting copper in aggressive sulfuric acid solution, Chem. Eng. J., 2020, 384, 123293.
[10] Wenhao Yin (本科生), Ling Fang, Zhiyong Wang (本科生), Fang Gao, Zhefeng Li*, Zhiyong Wang* Synthesis of Bicyclo[4.1.0]tetrahydropyridazines by a Sequential [4 + 2] and [1 + 2] Annulation Reaction of Azoalkenes and Crotonate-Derived Sulfur Ylides, Org. Lett. 2019, 21, 7361
[11] Zhiyong Wang (本科生), YanzhouYang, Fang Gao, Zhiyong Wang*, Qian Luo, Ling Fang* Synthesis of 5-(Trifluoromethyl)pyrazolines by Formal [4+1]-Annulation of Fluorinated Sulfur Ylides and Azoalkenes. Org. Lett. 2018, 20, 934–937. (IF=6.579)
[12] Wuyan Long (本科生), Shuangqun Chen, Xiaohong Zhang (本科生), Ling Fang, Zhiyong Wang*.Diversity-oriented synthesis of 1,2,3,5-tetrahydrobenzo[e][1,2,4]oxadiazepines and 2,3-dihydro-1H-benzo[e][1,2,4] triazepines by base-induced [4 + 3] annulation reactions, Tetrahedron 2018, 74, 6155-6165.
[13] Ling Fang, Lijun Xue, Peng Yang, Xiaodan Li, Zhiyong Wang* A Facile Route to 4-Polyfluoroarylquinolin-2(1H)-ones and 4-Polyfluoroarylcoumarins via C-H Bond Activation. Chem. Lett. 2017, 46, 1223–1226.
[14] Xiaozhuan Qin, Ge Ding, Ziping Luo, Zhiyong Wang, Shengtao Zhang, Hongru Li,* Fang Gao* A mild acid-free one-pot reaction for synthesis of new phenanthridine dyes. Dyes Pigments 2016, 134, 613.
[15] Zhen Chen, Zhiyong Wang* An efficient route to diverse 2H-pyrano[3,2-c]quinolin- 5(6H)-ones via electrophilic cyclization reactions. Tetrahedron 2016, 72, 4288.
[16] Zhiyong Wang*, Liun Xue, Yiyi He, Ling Fang* Access to Functionalized 3H-Pyrrolo[2,3-c]quinolin-4(5H)-ones and Thieno[2,3-c]quinolin-4(5H)-ones via Domino Reaction of 4-Alkynyl-3-bromo-quinolin-2(1H)-ones. J. Org. Chem. 2014, 79, 9628.
[17] Xianbo Wang, Liun Xue, Zhiyong Wang* A Copper-Catalyzed Three-Component Reaction of Triethoxysilanes, Sulfur Dioxide, and Hydrazines. Org. Lett. 2014, 16, 4056.
[18] Xianbo Wang, Zhiyong Wang* A tandem reaction of 2-alkynylbenzaldoximes with cyclic ethers co-catalyzed by silver(I) triflate and copper(II) acetate. Tetrahedron 2014, 70, 6728.
[19] Xianbo Wang, Zhiyong Wang* An approach to 1-phosphorylated isoquinolines through silver(I)-catalyzed tandem reaction involving C–N and C–P bond formation. Tetrahedron 2014, 70, 5720.
[20] Zhiyong Wang*, Xiaoxiao Xing, Liun Xue, Yan Xiong, Ling Fang* Iron(III) Chloride Catalyzed Formation of Aryl Hydrazides from Electron-Rich Arenes and Azodicarboxylates, Synthesis 2014, 757.
[21] Hongliang Liu, Zhiyong Wang*, Shouzhi Pu, Gang Liu* Synthesis of H-Pyrazolo[5,1-a]isoquinolines via Silver(I)-Catalyzed Tandem Reaction of N′-(2-Alkynylbenzylidene)hydrazides with Propargyl Amine Derivatives. Synthesis 2014, 600.
[22] Zhiyong Wang,* Xiaoxiao Xing, Lijun Xue, Fang Gao, Ling Fang* Synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones via Pd-catalyzed cross-coupling reaction and cyclization. Org. Biomol. Chem. 2013, 11, 7334.
[23] Hongliang Liu, Gang Liu*, Shouzhi Pu, Zhiyong Wang* A silver(I)-catalyzed tandem reaction of 2-alkynylbenzaldoxime with ketene. Org. Biomol. Chem. 2013, 11, 2898.
[24] Danqing Zheng, Zhiyong Wang*, Jie Wu* Silver triflate catalyzed reaction of 2-alkynylbenzaldoxime with phenol: a general and facile route to 1-aroxyisoquinolines, Synthesis, 2011, 2810.
独立工作前发表的文章：
[1] Zhipeng Yu, Yanchao Pan, Zhiyong Wang, Jiangyun Wang,* Qing Lin* Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells. Angew. Chem. Int. Ed. 2012, 51, 10600.
[2] Avinash Muppidi, Zhiyong Wang, Xiaolong Li, Jiandong Chen, Qing Lin* Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx. Chem. Commun. 2011, 47, 9396.
[3] Zhiyong Wang, Qiuping Ding, Xiaodan He, Jie Wu* Pd-catalyzed decarboxylative couplings of arenecarboxylic acids with aryl iodides. Tetrahedron 2009, 65, 4635.
[4] Zhiyong Wang, Qiuping Ding, Xiaodan He, Jie Wu* Pd-catalyzed decarboxylative cross-coupling reaction of cinnamic acid with aryl iodide. Org. Biomol. Chem. 2009, 7, 863.
[5] Zhiyong Wang, Xiaoyu Sun, Shengqing Ye, Weizi Wang, Bing Wang, Jie Wu* Quinine-catalyzed enantioselective desymmetrization of meso-aziridines with benzenethiols. Tetrahedron: Asymmetry 2008, 19, 964.
[6] Zhiyong Wang, Xiaoyu Sun, Jie Wu* FeCl3: an efficient catalyst for reactions of electron-rich arenes with imines or aziridines. Tetrahedron 2008, 64, 5013.
[7] Zhiyong Wang, Jie Wu* Synthesis of 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-ones via Pd-catalyzed region-selective cross-coupling reaction and cyclization. Tetrahedron 2008, 64, 1736.
[8] Zhiyong Wang, Renhua Fan, Jie Wu* Pd-catalyzed regioselective cross-coupling reactions of 3-bromo-4-tosyloxyquinolin-2(1H)-one with arylboronic acids. A facile and convenient route to 3, 4-disubstituted quinolin-2(1H)-ones. Adv. Synth. Catal. 2007, 349, 1943.
[9] Zhiyong Wang, Bing Wang, Jie Wu* Diversity-oriented synthesis of functionalized quinolin-2(1H)-ones via Pd-catalyzed site-selective cross-coupling reactions. J. Comb. Chem. 2007, 9, 811.
[10] Zhiyong Wang, Gang Zou*, Jie Tang. An unprecedented rhodium-catalyzed self-conjugate reduction, cross-coupling tandem reaction of cinnamaldehydes with arylboronic acids. Chem. Commun. 2004, 1192.
[11] Gang Zou*, Zhiyong Wang, Junru Zhu, Jie Tang. Rhodium-catalyzed Heck-type reaction of arylboronic acids with α, β-unsaturated esters: tuning β-hydrogen elimination vs. hydrolysis of alkylrhodium species. Chem. Commun. 2003, 2438.
[12] Gang Zou*, Zhiyong Wang, Junru Zhu, Jie Tang, Mingyuan He. Developing an ionic medium for ligandless-palladium-catalyzed Suzuki and Heck couplings. J. Mol. Cata. A: Chemical 2003, 206, 193.
团队仪器设备
